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Overview of the different types of peroxisomal disorders
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Peroxisomal disorders can be divided into primary and secondary peroxisomal enzyme deficiencies. The primary peroxisomal enzyme deficiency disorders (also known as single peroxisomal enzyme deficiencies) are directly caused by mutations in genes encoding peroxisomal enzymes. The secondary (indirect) peroxisomal enzyme deficiencies consist of RCDP type 1 and the Zellweger spectrum disorders and are caused by mutations in peroxisomal biogenesis genes which encode the peroxisomal biogenesis factors involved in the build-up of functional peroxisomes.
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